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Updated: Jul 4, 2026
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Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum
Published on: May 22, 2018
SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum
Feng Liu1, Ping Chen, Shu-Jian Cui
1Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, PR China. liuf@chgc.sh.cn
BMC Genomics
|June 27, 2008
Summary
A new database, SjTPdb, integrates transcriptomic and proteomic data for Schistosoma japonicum, aiding schistosomiasis research. This resource facilitates the study of schistosome biology and evolution for millions affected by this parasitic disease.
Area of Science:
- Parasitology
- Genomics
- Bioinformatics
Background:
- Schistosomiasis, caused by Schistosoma japonicum, is a significant global health issue affecting 200 million people.
- Abundant transcriptomic and proteomic data for S. japonicum are available, offering insights into its gene expression.
- Existing data require efficient integration for comprehensive analysis of schistosome biology.
Purpose of the Study:
- To establish SjTPdb, a public, searchable database integrating transcriptomic and proteomic data for Schistosoma japonicum.
- To enhance accessibility and utility of schistosome data for research.
- To facilitate studies on schistosome biology, physiology, and evolution.
Main Methods:
- Compilation of all available ESTs, EST clusters, and proteomic datasets for S. japonicum.
- Development of a core database featuring 8,420 annotated S. japonicum proteins.
- Implementation of a PHP-based web interface for browsing, querying (text, BLAST, developmental stage), and external database linkage.
Main Results:
- SjTPdb is the first comprehensive database for schistosome proteins with detailed annotations.
- It integrates both transcriptome and proteome data for S. japonicum.
- The database provides annotations on sequence similarity, structural features, functional ontology, genomic variations, and expression patterns.
Conclusions:
- SjTPdb serves as a valuable, integrated resource for schistosome functional genomics.
- It is the first database to combine transcriptome and proteome data for S. japonicum.
- The platform supports research into schistosome biology, disease mechanisms, and potential therapeutic targets.
