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Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper
Published on: January 19, 2024
Low-grade gliomas in adults
Sandeep Mittal1, Mark C Szlaczky, Geoffrey R Barger
1Geoffrey R. Barger, MD Department of Neurology, Karmanos Cancer Institute, Wayne State University, 4201 St. Antoine, Suite 8D, Detroit, MI 48201, USA. gbarger@med.wayne.edu.
Current Treatment Options in Neurology
|June 27, 2008
Summary
Treatment for low-grade gliomas (LGGs) involves surgery, radiation, and chemotherapy. Maximal surgical resection is recommended, and temozolomide shows promise. Lifelong MRI follow-up is advised for these challenging brain tumors.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiation Oncology
- Medical Oncology
Background:
- Low-grade gliomas (LGGs) present diagnostic and therapeutic challenges.
- Optimal management strategies for LGGs are still being investigated.
- Patients often have seizures with minimal initial neurological deficits.
Purpose of the Study:
- To review current understanding and recommendations for managing infiltrating low-grade gliomas.
- To highlight the roles of surgery, radiation, and chemotherapy in LGG treatment.
- To emphasize the need for continued research and clinical trial participation.
Main Methods:
- Review of existing literature and clinical trial data.
- Discussion of surgical resection principles and radiation therapy protocols.
- Evaluation of chemotherapy agents, including temozolomide, and predictive biomarkers.
Main Results:
- Maximal surgical resection, preserving neurological function, is a cornerstone of LGG management.
- Radiation therapy, typically 50.4-54 Gy, plays a significant role.
- Temozolomide demonstrates activity in LGG treatment, and 1p/19q and MGMT status are predictive markers.
Conclusions:
- A multimodal approach combining maximal surgical resection, radiation therapy, and potentially chemotherapy is recommended for LGGs.
- Early radiation therapy may improve time to tumor progression.
- Lifelong MRI surveillance is crucial for monitoring tumor progression in LGG patients.
