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Updated: Jul 4, 2026

Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Glioblastoma multiforme.

Herbert B Newton1

  • 1Herbert B. Newton, MD Dardinger Neuro-Oncology Center, Department of Neurology, Ohio State University Medical Center, 465 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA. newton.12@osu.edu.

Current Treatment Options in Neurology
|June 27, 2008
PubMed
Summary

Newly diagnosed glioblastoma multiforme patients require maximal tumor resection and clinical trial enrollment. Standard care involves radiation with temozolomide, with bevacizumab and irinotecan as a salvage option.

Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Medical Oncology

Background:

  • Glioblastoma multiforme is an aggressive primary brain tumor.
  • Optimal treatment strategies are continuously evolving.

Purpose of the Study:

  • To outline the current standard of care for newly diagnosed glioblastoma multiforme.
  • To discuss alternative and investigational treatment approaches.

Main Methods:

  • Maximal tumor resection followed by chemoradiation.
  • Adjuvant temozolomide chemotherapy.
  • Salvage therapy with bevacizumab and irinotecan.
  • Investigation of molecular therapies targeting growth factor receptors and signal transduction pathways.

Main Results:

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  • Standard treatment combines external beam irradiation (60 Gy) with daily low-dose temozolomide, followed by adjuvant temozolomide cycles.
  • Bevacizumab and irinotecan show activity when standard therapy fails.
  • Molecular therapies are under active investigation.

Conclusions:

  • Maximal resection and clinical trial participation are recommended for glioblastoma patients.
  • Current treatment involves a combination of radiation and temozolomide.
  • Emerging molecular therapies hold promise for future glioblastoma treatment.