Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 4, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

Anaplastic oligodendroglioma.

Jaishri Blakeley1, Stuart Grossman

  • 1Jaishri Blakeley, MD Brain Cancer Program, Johns Hopkins University, Cancer Research Building 2, 1550 Orleans, Suite 1M16, Baltimore, MD 21231, USA. jblakel3@jhmi.edu.

Current Treatment Options in Neurology
|June 27, 2008
PubMed
Summary

Anaplastic oligodendrogliomas (AODs) require prompt recognition and diagnosis. While surgery and radiation are standard, chemotherapy

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequential, Noninvasive, Neurosensory Monitoring During Chemotherapy: Clinical Consequences of Identifying Neuropathy.

Journal of reconstructive microsurgery·2026
Same author

Outcome measures for cutaneous neurofibromas in NF1: Insights from an international study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

The 9th International RASopathies Symposium.

American journal of medical genetics. Part A·2026
Same author

Clinical Outcomes Following Surgical Resection for Patients With Malignant Peripheral Nerve Sheath Tumors.

Neurosurgery·2026
Same author

Variant Resolution Through RNA Testing and Affected Tissue Analysis in the Neurofibromatoses: A Case Series.

Neurology. Genetics·2026
Same author

Low-Dose Fractionated Radiation Therapy as a Chemopotentiator of Temozolomide for Recurrent Anaplastic Astrocytoma and Glioblastoma: A Single-Arm Phase 1/2 Trial.

International journal of radiation oncology, biology, physics·2025

Area of Science:

  • Neuro-oncology
  • Molecular diagnostics
  • Brain tumor research

Background:

  • Anaplastic oligodendrogliomas (AODs) are rare but distinct brain tumors.
  • Early recognition via MRI and maximal resection are crucial for diagnosis and symptom relief.
  • Standard treatment involves surgery and radiation therapy (XRT), with chemotherapy's role evolving.

Purpose of the Study:

  • To review the current understanding and management of anaplastic oligodendrogliomas.
  • To highlight the significance of molecular markers, particularly 1p19q codeletion, in AOD prognosis and treatment.
  • To discuss ongoing research and future directions in AOD therapy.

Main Methods:

  • Review of existing literature on AOD diagnosis, treatment, and molecular markers.
  • Analysis of findings from prospective phase 3 trials regarding chemotherapy efficacy.
  • Emphasis on the diagnostic and prognostic value of 1p19q codeletion assessment.

Main Results:

  • PCV chemotherapy added to XRT did not improve overall survival in newly diagnosed AOD patients.
  • 1p19q codeletion is a critical marker for oligodendroglial differentiation, predicting a better prognosis.
  • Ongoing trials are investigating temozolomide's role and the utility of 1p19q status in treatment planning.

Conclusions:

  • AOD remains a challenging diagnosis, necessitating integrated treatment approaches.
  • 1p19q codeletion status is vital for understanding prognosis and guiding clinical trial enrollment.
  • Further research is needed to optimize AOD treatment based on molecular profiles and novel therapies.

More Related Videos

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Related Experiment Videos

Last Updated: Jul 4, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017