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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jul 4, 2026

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
07:43

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Published on: February 8, 2017

Brain metastases.

April F Eichler1, Scott R Plotkin

  • 1Scott R. Plotkin, MD, PhD Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA. splotkin@partners.org.

Current Treatment Options in Neurology
|June 27, 2008
PubMed
Summary
This summary is machine-generated.

Metastatic brain tumors are common in cancer patients. Treatment involves surgery, radiation, and chemotherapy, with local therapies offering improved outcomes for limited metastases.

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Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
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Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

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Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
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Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

Related Experiment Videos

Last Updated: Jul 4, 2026

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
07:43

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Published on: February 8, 2017

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
07:42

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

Area of Science:

  • Neuro-oncology
  • Cancer Metastasis
  • Intracranial Neoplasms

Background:

  • Metastatic brain tumors are the most common intracranial neoplasm in adults, affecting up to 10% of cancer patients in the US.
  • Incidence is rising due to aging populations, improved systemic disease treatment, and advanced cranial imaging.
  • Lung cancer, breast cancer, and melanoma are the most frequent primary sources.

Purpose of the Study:

  • To review current therapeutic approaches for brain metastases.
  • To discuss the role of various treatments including surgery, radiotherapy, and chemotherapy.
  • To highlight emerging research directions for expanded treatment options.

Main Methods:

  • Review of therapeutic modalities for brain metastases.
  • Analysis of treatment outcomes based on prognostic factors.
  • Discussion of current and future systemic treatment strategies.

Main Results:

  • Whole brain radiotherapy (WBRT) is widely used, but local therapies like surgery and stereotactic radiosurgery (SRS) improve outcomes for limited metastases.
  • SRS is effective for recurrent lesions.
  • Chemotherapy is typically a salvage option, but systemic therapies are a focus for future research.

Conclusions:

  • Treatment decisions for brain metastases require careful consideration of prognostic factors to balance efficacy and toxicity.
  • Local therapies offer survival and functional benefits for select patients.
  • Future research will likely emphasize systemic treatments, novel drug delivery, and overcoming resistance mechanisms.