Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The High-Energy Ion Telescope (HIT) for the Interstellar Mapping And Acceleration Probe (IMAP) Mission.

Space science reviews·2026

Same author

The complexity of finding fit-for-purpose real-world data for oncology patients with rare <i>NTRK</i> gene fusions and a novel solution.

ESMO real world data and digital oncology·2026

Same author

IMAP's Role in Understanding Particle Injection and Energization Throughout the Heliosphere.

Space science reviews·2026

Same author

Precision Spectral Measurements of Chromium and Titanium from 10 to 250 GeV/n and Sub-Iron to Iron Ratio with the Calorimetric Electron Telescope on the International Space Station.

Physical review letters·2025

Same author

CC486 as a safe and effective bridge to transplant in MDS-del5q with transfusion-dependent anemia following lenalidomide relapse: A case report.

Current research in translational medicine·2025

Same author

AI Revolution in Radiology, Radiation Oncology and Nuclear Medicine: Transforming and Innovating the Radiological Sciences.

Journal of medical imaging and radiation oncology·2025

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

The relation between paracetamol use and asthma: a GA2LEN European case-control study.

S Shaheen¹, J Potts, L Gnatiuc

¹National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK. s.shaheen@imperial.ac.uk

The European Respiratory Journal

|June 27, 2008

Summary

Frequent use of paracetamol (acetaminophen) is linked to a higher risk of adult asthma across Europe. This study adds to evidence suggesting paracetamol may contribute to asthma development.

Related Experiment Videos

Last Updated: Jul 4, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

Epidemiology
Allergology
Pharmacology

Background:

Previous studies in the UK and USA indicated a potential link between frequent paracetamol (acetaminophen) use and asthma risk.
Data on this association across European populations were limited.

Purpose of the Study:

To investigate the association between frequent paracetamol use and adult asthma in a multicentric European study.
To expand on existing epidemiological evidence regarding paracetamol and asthma risk.

Main Methods:

A multicentric case-control study involving 521 adult asthma cases and 507 controls across 12 European centers.
Participants were aged 20-45 years and selected from the same residential populations.
A random effects meta-analysis was employed to assess the association, controlling for confounders.

Main Results:

Weekly paracetamol use showed a strong positive association with asthma compared to less frequent use.
No significant heterogeneity was observed across the participating European centers.
No association was found between the use of other analgesics and asthma.

Conclusions:

Frequent paracetamol use is significantly associated with adult asthma in diverse European populations.
The findings support existing epidemiological evidence implicating paracetamol in asthma development.
Further research may be warranted to elucidate the mechanisms behind this association.