Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa01:22

Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa

The pH of urine, the drug's pKa, and the urine flow rate are vital parameters for drug reabsorption and excretion. Urinary pH varies between 4.6 and 8.0 and is influenced by diet, drug intake, and the patient's pathophysiology. It affects a drug's ionization state and reabsorption. For instance, carbohydrate-rich food produces alkaline urine promoting drug excretion, while proteins and certain medications like ascorbic acid lead to acidic urine enhancing reabsorption.
The pKa of a drug,...
Renal Drug Excretion: Tubular Reabsorption01:25

Renal Drug Excretion: Tubular Reabsorption

Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
One-Compartment Open Model: Urinary Excretion Data and Determination of k01:11

One-Compartment Open Model: Urinary Excretion Data and Determination of k

The one-compartment open model leverages urinary excretion data to estimate renal clearance, which gauges the kidney's capacity to expel a drug. This method offers several benefits, including directly measuring drug elimination and assessing the kidney's contribution to overall drug clearance. However, this approach has limitations. It assumes sole renal excretion of the drug, which is not true for all drugs. Accurate urinary excretion and plasma drug concentration measurement can also be...
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Regulation of Sodium and Potassium01:26

Regulation of Sodium and Potassium

The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conducting multicenter trials through the trial innovation network comprehensive consultation.

Contemporary clinical trials·2026
Same author

DASH-patterned groceries and effects on blood pressure in adults treated for hypertension: the GoFreshRx randomized trial.

Nature medicine·2026
Same author

Effects of dietary patterns and sodium intake on blood pressure variability: results from the DASH and DASH-sodium trials.

Journal of hypertension·2026
Same author

DASH-Patterned Groceries and Effects on Blood Pressure: The GoFresh Randomized Clinical Trial.

JAMA·2025
Same author

Modification of the Association Between Hearing Trouble and Satisfaction With Care by Accompaniment to Health Care Visits.

Journal of the American Geriatrics Society·2025
Same author

Insights from the trial innovation network's initial consultation process.

Journal of clinical and translational science·2025
Same journal

Variants to Functions to Therapeutic Strategies Toward Genomically Informed Care for Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Personalizing Cardio-Kidney-Metabolic Therapy: Closer But Not There Yet.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Autosomal Dominant Tubulointerstitial Kidney Disease: My Kingdom for a Biomarker.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Beyond the Margin: Improving Noninferiority Trials of Kidney Transplant Immunosuppression.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Parathyroid Hormone Receptor 1 Facilitates Cyst Growth in Genetic Models of Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Alanyl-tRNA Synthetase 1 and Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

Racial differences in urinary potassium excretion.

Sharon Turban1, Edgar R Miller, Brett Ange

  • 1Division of Nephrology, Johns Hopkins University School of Medicine, 1830 E. Monument Street, Suite 416, Baltimore, MD 21205, USA. sturban1@jhmi.edu

Journal of the American Society of Nephrology : JASN
|June 27, 2008
PubMed
Summary
This summary is machine-generated.

Racial disparities in urinary potassium excretion persist even with similar dietary intake. Black individuals consistently excrete less potassium than white individuals, suggesting factors beyond diet influence this difference.

More Related Videos

A Modified Precipitation Method to Isolate Urinary Exosomes
05:05

A Modified Precipitation Method to Isolate Urinary Exosomes

Published on: January 16, 2015

Related Experiment Videos

Last Updated: Jul 4, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

A Modified Precipitation Method to Isolate Urinary Exosomes
05:05

A Modified Precipitation Method to Isolate Urinary Exosomes

Published on: January 16, 2015

Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Racial Health Disparities

Background:

  • Higher blood pressure (BP) in Black individuals compared to White individuals may be linked to racial differences in potassium (K) intake and excretion.
  • Black individuals typically consume less dietary K, but their lower urinary K excretion suggests other factors are involved.

Purpose of the Study:

  • To investigate urinary K excretion differences between Black and White individuals with similar K intake using data from the DASH trial.
  • To determine if racial disparities in urinary K excretion persist independent of dietary K intake.

Main Methods:

  • Analysis of data from 413 White and Black participants in the DASH trial.
  • Assessment of urinary K excretion at screening, after a low-K run-in period, and after an 8-week intervention with control, high fruit/vegetable, or DASH diets.
  • Statistical adjustments for age, gender, weight, and caloric intake.

Main Results:

  • Initially, White individuals excreted significantly more urinary K than Black individuals (mean difference 645 mg/d).
  • This difference remained significant after a low-K diet (mean difference 201 mg/d).
  • Post-intervention, significant differences were observed in the DASH group (903 mg/d higher in White individuals, P < 0.001), but not in the control or fruit/vegetable groups.

Conclusions:

  • Racial differences in urinary K excretion appear to be influenced by factors beyond dietary K intake.
  • Further research is needed to understand the clinical implications of these racial disparities in K excretion.