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Burn Injuries

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Related Experiment Video

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A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Gender differences in pediatric burn patients: does it make a difference?

Marc G Jeschke¹, Ronald P Mlcak, Celeste C Finnerty

¹Shriners Hospitals for Children, Galveston, Texas 77550, USA. majeschk@utmb.edu

Annals of Surgery

|June 27, 2008

Summary

This summary is machine-generated.

Severely burned children show that females have a reduced inflammatory and hypermetabolic response compared to males. This leads to better muscle protein balance and lean body mass preservation, resulting in shorter intensive care unit (ICU) stays.

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Area of Science:

Pediatric critical care medicine
Burn injury research
Physiology and metabolism

Background:

Severe burns (>40% total body surface area) in 189 pediatric patients.
Study cohort divided into females (n=76) and males (n=113).

Purpose of the Study:

Compare hospital course and physiological markers between severely burned pediatric females and males.
Investigate sex-based differences in outcomes following severe burn injuries.

Main Methods:

Analysis of patient demographics, clinical parameters, and mortality.
Measurement of muscle protein synthesis, resting energy expenditure (REE), and body composition.
Assessed serum hormones, cytokines, cardiac function, and liver size.

Main Results:

No significant differences in mortality, demographics, burn size, or injuries between sexes.
Females exhibited shorter intensive care unit (ICU) stays (29 vs. 38 days).
Females demonstrated attenuated inflammatory markers, reduced hypermetabolism, improved muscle protein net balance, preserved lean body mass, and better cardiac/liver function.

Conclusions:

Female pediatric burn patients show an attenuated inflammatory and hypermetabolic response compared to males.
This reduced response correlates with improved muscle protein balance and lean body mass preservation.
These physiological differences contribute to a shortened hospital stay in female burn patients.