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Related Experiment Video

Updated: Jul 4, 2026

Isolation of Brain-infiltrating Leukocytes

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

Postinfectious focal necrotizing myopathy.

Manuel Dafotakis¹, Roland Sparing, Simon B Eickhoff

¹Department of Neurology, University Hospital, University of Cologne, Cologne, Germany. sylviaderyk@hotmail.com

Clinical Nuclear Medicine

|June 27, 2008

Summary

This summary is machine-generated.

A postinfectious immunologic reaction caused vasculitic necrotizing myopathy in a woman presenting with leg pain after a cold. This condition involved inflammation and damage to small blood vessels in the lower legs.

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Isolation of Brain-infiltrating Leukocytes

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Published on: June 13, 2011

A Neonatal Mouse Model of Necrotizing Enterocolitis and Lamina Propria Isolation for Immune Cell Profiling

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Published on: September 19, 2025

Area of Science:

Rheumatology
Neurology
Immunology

Background:

Postinfectious immunologic reactions can manifest with diverse systemic symptoms.
Vasculitic myopathies are rare but serious complications following infections.

Observation:

A 37-year-old woman presented with fatigue, fever, and asymmetric lower leg pain two weeks post-common cold.
Skeletal scintigraphy showed increased soft tissue perfusion and tracer uptake in the lower legs, indicating inflammation.
Muscle biopsy confirmed vasculitic necrotizing myopathy affecting small vessels.

Findings:

The patient's symptoms and biopsy results were consistent with a postinfectious immunologic reaction.
The condition primarily involved necrotizing inflammation of small blood vessels in the lower leg musculature.
Technetium-99m hydroxymethylene diphosphonate (Tc-99m HDP) scintigraphy aided in identifying the inflammatory etiology.

Implications:

This case highlights the importance of considering immunologic reactions following common infections.
Early diagnosis and management of vasculitic myopathy are crucial to prevent complications.
Further research into the specific immunologic pathways involved in postinfectious vasculitis is warranted.