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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Bone scan findings in metastatic calcification from calciphylaxis.

Sushane Soni¹, William D Leslie

¹Section of Nuclear Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Clinical Nuclear Medicine

|June 27, 2008

Summary

Calciphylaxis, a severe complication of chronic renal failure, involves widespread calcification. Sodium thiosulfate treatment showed significant improvement in a patient with this condition.

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Area of Science:

Nephrology
Radiology
Dermatology

Background:

Peritoneal dialysis is a treatment for chronic renal failure.
Diabetic nephropathy and NSAID nephropathy are common causes of chronic renal failure.
Calciphylaxis (calcific uremic arteriolopathy) is a rare but serious complication in patients with chronic renal failure.

Observation:

A 51-year-old woman undergoing peritoneal dialysis presented with firm subcutaneous plaques.
A Technetium-99m MDP bone scan was performed to evaluate the plaques.
The scan revealed extensive superficial tracer localization and visceral tracer activity.

Findings:

The scintigraphic findings were characteristic of calciphylaxis.
This condition involves metastatic calcification, primarily in subcutaneous tissues.
It is associated with painful ulcerations, high morbidity, and mortality.

Implications:

Early diagnosis and treatment of calciphylaxis are crucial.
Sodium thiosulfate demonstrated significant improvement in scintigraphic findings.
This highlights the potential of sodium thiosulfate in managing calciphylaxis.