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Updated: Jul 4, 2026

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

Surviving blood loss using hydrogen sulfide.

Michael L Morrison¹, Jennifer E Blackwood, Summer L Lockett

¹Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

The Journal of Trauma

|June 27, 2008

Summary

This summary is machine-generated.

Hydrogen sulfide gas or liquid administration significantly improved survival rates in rats experiencing lethal hemorrhage. This suggests hydrogen sulfide offers protection against blood loss-related injuries.

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Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

Area of Science:

Biomedical Research
Physiology
Toxicology

Background:

Reduced metabolic activity is a key factor in improving outcomes for injuries and diseases involving insufficient blood supply.
Hydrogen sulfide (H2S) gas has been shown to reversibly reduce metabolic activity in experimental models.
This study investigates the potential protective benefits of hydrogen sulfide in conditions of insufficient blood supply.

Purpose of the Study:

To determine if hydrogen sulfide administration confers survival benefits in rats subjected to lethal hemorrhage.
To evaluate the efficacy of both inhaled gaseous and intravenous liquid hydrogen sulfide administration.

Main Methods:

Sprague-Dawley rats underwent controlled hemorrhage, removing 60% of total blood volume.
Hydrogen sulfide was administered via inhaled gas or intravenous infusion.
Survival rates were the primary outcome measure, analyzed using log-rank analysis.

Main Results:

Inhaled H2S increased survival from 23% to 75%; intravenous H2S increased survival from 14% to 67% (p < 0.001).
Surviving rats exhibited no functional or behavioral abnormalities.
Hydrogen sulfide stabilized metabolic output during and after hemorrhage, with minor blood chemistry differences observed.

Conclusions:

Sulfide administration effectively protects rats against lethal hemorrhage.
Further research is warranted to elucidate the underlying mechanisms of benefit and explore efficacy in other injury and disease models.