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Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...

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Related Experiment Video

Updated: Jul 4, 2026

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

Orthostatic hemodynamic changes after electroconvulsive therapy treatments.

Keith G Rasmussen1, Angela D Leise, Susanna R Stevens

  • 1Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA. rasmussen.keith@mayo.edu

The Journal of ECT
|June 27, 2008
PubMed
Summary

Falls after electroconvulsive therapy (ECT) are often due to orthostatic hypotension. This study found no link between common anesthetic medications or ECT electrode placement and this post-treatment drop in blood pressure.

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Last Updated: Jul 4, 2026

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

Area of Science:

  • Anesthesiology
  • Neurology
  • Critical Care Medicine

Background:

  • Falls are a significant concern for patients undergoing electroconvulsive therapy (ECT).
  • Orthostatic hypotension, a drop in blood pressure upon standing, is a known contributor to post-ECT falls.
  • Identifying modifiable factors influencing hemodynamic instability after ECT is crucial for patient safety.

Purpose of the Study:

  • To investigate the association between modifiable anesthetic factors and post-ECT orthostatic hypotension.
  • To assess the impact of specific perianesthetic medications and ECT technical variables on hemodynamic changes.

Main Methods:

  • A prospective study involving 62 patients receiving 295 ECT treatments.
  • Measurement of supine and standing blood pressure and pulse approximately 2 hours after ECT.
  • Multivariate analysis to evaluate the association of perianesthetic medications (labetalol, glycopyrrolate, remifentanil) and ECT variables (seizure duration, electrode placement) with orthostatic changes.

Main Results:

  • A mean decrease of -5.25 mm Hg in systolic pressure, 1.5 mm Hg in diastolic pressure, and -17.0 beats per minute in pulse was observed post-treatment.
  • No statistically significant association was found between the use of commonly administered perianesthetic medications and orthostatic hypotension.
  • Variations in ECT technical parameters, including seizure duration and electrode placement, were not associated with orthostatic blood pressure drop.

Conclusions:

  • Commonly used perianesthetic medications do not appear to contribute to orthostatic hypotension following ECT.
  • Technical aspects of ECT, such as electrode placement, are not associated with post-treatment orthostatic hypotension.
  • Further research may be needed to identify other potential causes or preventative strategies for post-ECT falls related to hemodynamic instability.