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QEEG changes during switch from depression to hypomania/mania: a case report.
Miloslav Kopecek1, Barbora Tislerova, Peter Sos
1Prague Psychiatric Centre; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic. kopecek@pcp.lf3.cuni.cz
Neuro Endocrinology Letters
|June 27, 2008
Summary
Quantitative EEG (QEEG) cordance changes in theta prefrontal activity may precede mood shifts in bipolar disorder, similar to unipolar depression findings. This suggests QEEG
Area of Science:
- Neuroscience
- Psychiatry
- Quantitative Electroencephalography (QEEG)
Background:
- QEEG cordance and Low-Resolution Electromagnetic Tomography (LORETA) are emerging neuroimaging techniques.
- Previous studies indicated that reduced QEEG prefrontal theta cordance predicts antidepressant response in unipolar depression.
Observation:
- A case study of a 54-year-old male with bipolar disorder explored QEEG cordance and LORETA.
- No decrease in prefrontal theta cordance was observed with initial antidepressant treatment, correlating with non-response.
- A decrease in prefrontal theta cordance preceded a switch to hypomania following clomipramine therapy.
Findings:
- A significant threefold change in theta prefrontal cordance preceded mood changes in a bipolar patient.
- LORETA revealed increased theta activity in the right postcentralis gyrus and borderline increased alfa2 in the right middle frontal gyrus during clomipramine treatment.
- These QEEG changes mirrored patterns observed in unipolar depression.
Implications:
- QEEG applications may be sensitive to mood fluctuations in bipolar disorder.
- Findings suggest potential utility of QEEG in bipolar disorder research and monitoring.
- Observed LORETA changes might relate to clomipramine's anticholinergic effects and mood switching phenomena.
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