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Updated: Jul 4, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Trichosporon asahii fatal infection in a preterm newborn]
Carlos J Téllez-Castillo1, María Gil-Fortuño, Irene Centelles-Sales
1Laboratorio de Microbiología y Parasitología, Hospital General de Castellón, Castellón de la Plana, España. cartecas@gmail.com
Abstract:
We present a case of Trichosporon asahii fatal infection recognized post mortem in a premature newborn baby of 685 g. Trichosporon asahii isolated from endovascular catheters and endotraqueal tube, is an opportunistic yeast described like an emergent pathogen in serious systemic infections and nosocomial infections in the neonatal intensive care units. The colonization and disease by this uncommon microorganism, usually is unspecific and has similar clinical presentation to other fungal infections with a bad prognosis.
Insights
A premature newborn experienced a fatal Trichosporon asahii infection, identified post mortem. This opportunistic yeast is an emerging pathogen in neonatal intensive care units, often presenting with non-specific symptoms and poor outcomes.
Area of Science:
- Medical Mycology
- Neonatal Infectious Diseases
Background:
- Trichosporon asahii is an opportunistic yeast.
- It is recognized as an emergent pathogen in neonatal intensive care units (NICUs).
- Infections are often associated with invasive devices like catheters and endotracheal tubes.
Observation:
- A case of fatal Trichosporon asahii infection in a premature neonate (685g) is presented.
- The infection was identified post mortem.
- The yeast was isolated from endovascular catheters and an endotracheal tube.
Findings:
- Trichosporon asahii can cause serious systemic and nosocomial infections in neonates.
- Colonization and disease presentation are often non-specific.
- Clinical presentation is similar to other fungal infections, indicating a poor prognosis.
Implications:
- Highlights the potential severity of Trichosporon asahii in vulnerable neonates.
- Emphasizes the need for increased awareness and diagnostic vigilance for this pathogen in NICUs.
- Suggests that early recognition and management may be crucial for improving outcomes in neonatal fungal infections.
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