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Related Experiment Videos

Gibberellic acid by solid state fermentation: Consistent and improved yields.

P K Kumar1, B K Lonsane

  • 1Fermentation Technology and Bioengineering Discipline, Central Food Technological Research Institute, Mysore 570 013, India.

Biotechnology and Bioengineering
|August 5, 1987
PubMed
Summary
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Solid state fermentation (SSF) with Gibberella fujikuroi P-3 significantly enhances gibberellic acid (GA(3)) production compared to submerged fermentation (SmF). Optimizing substrate and particle size further boosts GA(3) yields, demonstrating SSF

Area of Science:

  • Biotechnology
  • Industrial Microbiology
  • Biochemical Engineering

Background:

  • Gibberellic acid (GA(3)) is a crucial plant hormone with wide agricultural applications.
  • Current production methods often rely on submerged fermentation (SmF), which can be costly and less efficient.
  • Optimizing fermentation techniques is essential for sustainable and cost-effective GA(3) production.

Purpose of the Study:

  • To screen strains of Gibberella fujikuroi for consistent gibberellic acid (GA(3)) production.
  • To compare the efficacy of solid state fermentation (SSF) versus submerged fermentation (SmF) for GA(3) yield.
  • To optimize SSF parameters for enhanced GA(3) accumulation.

Main Methods:

  • Screening of five strains each of Gibberella fujikuroi and Fusarium monoliforme.

Related Experiment Videos

  • Comparative analysis of GA(3) production using SSF and SmF techniques.
  • Optimization of substrate (wheat bran) particle size and enrichment with soluble starch.

    • Main Results:

    • Selected strain G. fujikuroi P-3 demonstrated consistent GA(3) production via SSF.
    • SSF resulted in 1.626 times higher GA(3) accumulation compared to SmF.
    • Optimized SSF using coarse wheat bran (0.3-0.4 cm) and soluble starch enrichment increased GA(3) yield by 2.5 and 3.5 times, respectively.
    • Achieved yields of 1.22 g GA(3)/kg dry moldy bran (DMB).

    Conclusions:

    • Solid state fermentation (SSF) is a superior technique for GA(3) production by G. fujikuroi P-3.
    • Optimized SSF offers significant potential for cost-effective GA(3) manufacturing.
    • SSF presents a feasible and economical alternative to SmF for industrial GA(3) production, with projected savings of ~60% on medium costs and ~50% on downstream processing.