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Related Experiment Video

Updated: Jul 4, 2026

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration

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Published on: May 19, 2023

T2 and T2* quantification using optimal B1 image reconstruction for multicoil arrays.

Martin J Graves¹, Daniel Emmens, Hubert Lejay

¹Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Hills Road, Cambridge, UK. mjg40@radiol.cam.uk

Journal of Magnetic Resonance Imaging : JMRI

|June 27, 2008

Summary

Optimal B(1) image reconstruction (OBR) improves accuracy in low signal-to-noise ratio (SNR) T(2) and T(2)* measurements compared to standard root sum of squares (RSS) reconstruction. OBR provides more accurate results, especially when SNR is limited.

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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

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Published on: December 18, 2016

Area of Science:

Magnetic Resonance Imaging (MRI)
Biomedical Engineering
Medical Physics

Background:

Accurate T(2) and T(2)* measurements are crucial for MRI diagnostics.
Low signal-to-noise ratio (SNR) can compromise measurement accuracy.
Standard root sum of squares (RSS) reconstruction may be suboptimal in low SNR conditions.

Purpose of the Study:

To evaluate the accuracy of T(2) and T(2)* measurements using array coils with optimal B(1) image reconstruction (OBR).
To compare OBR with standard root sum of squares (RSS) reconstruction for low SNR T(2) and T(2)* measurements.

Main Methods:

In vitro studies using calibrated gels for T(2) measurements.
In vivo T(2) and T(2)* measurements in a volunteer's knee and liver using multiecho spin echo and gradient echo sequences, respectively.
Deliberately low SNR acquisition and comparison of OBR with RSS reconstruction using identical raw data.

Main Results:

OBR reconstructions exhibited lower mean background noise compared to RSS.
In vitro T(2) measurements with OBR showed better agreement with reference values than RSS.
In vivo studies indicated that RSS overestimated relaxation times, particularly at lower signal averages.

Conclusions:

OBR enhances the accuracy of T(2) and T(2)* measurements in low SNR scenarios.
OBR offers a significant improvement over RSS reconstruction for quantitative MRI relaxometry.
This method is particularly beneficial for applications requiring precise measurements under challenging SNR conditions.