Related Experiment Video
Updated: Jul 4, 2026
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
[A method designed for the assessment of myocardial metabolism in rats with 18F-FDG using small-animal-PET. Initial
Erick Alexánderson Rosas1, Nayelli Ortega López, Rafael Ojeda Flores
1Universidad Nacional Autónoma de México (UNAM), Facultad de Medicina, Ciudad Universitaria, México, D.F. 04510. alexanderick@yahoo.com.mx
Purpose:
To standarize an acquisition protocol for the study of myocardial metabolism in adult rats.
Material And Methods:
Three Wistar adult male rats were studied in three different protocols: no fasting group, fasting group over a period of 12 hr before the study with only water provided ad libitum, and fasting group by the same time receiving an oral 50% glucose solution. Thirty-minute acquisition images were obtained with a micro-PET, thirty and sixty minutes after the administration of 370-555 MBq 18F-FDG. Comparative and visual analysis were performed by two experts in the field.
Results:
Eigtheen studies were analyzed, six per group. The best images were those of the first group, especially those taken at 60 minutes after the 18F-FDG administration.
Conclusion:
It is possible to establish the non-fasting protocol for the assessment of myocardial metabolism to be used in the future for the myocardial viability evaluation in ischemic cardiopathy.
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