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Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
Published on: March 18, 2020
Pediatric human immunodeficiency virus infection and circulating IgD+ memory B cells
Marianne C Jacobsen1, Rodolphe Thiébaut, Christopher Fisher
1Infectious Diseases and Microbiology Unit, Hugh and Catherine Stevenson Centre for Childhood Infectious Diseases and Immunology, Institute of Child Health, University College London, United Kingdom.
Abstract:
Levels of circulating naive and memory B cells were measured in human immunodeficiency virus (HIV)-infected children and control subjects to determine whether the irreversible depletion of memory B cells described in HIV-infected adults occurs in children with HIV infection. Depletion of circulating IgD+ memory B cells was seen in HIV-infected children despite control of the HIV load with highly active antiretroviral therapy (HAART) (P =. 04). IgD+ memory B cell percentages did not correlate with CD4+ cell percentages (P =. 027) or disease duration (P =. 026). Naive/transitional and IgD- memory B cell numbers were not affected. Pediatric HIV infection is associated with selective depletion of circulating IgD+ memory B cells despite control of the HIV load with HAART.
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