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Snake venom or antivenom induced urticaria
1Division of Clinical Pharmacology/Toxicology, Hennepin County Medical Center, Minneapolis, Minnesota 55415.
Veterinary and Human Toxicology
|June 1, 1991
Summary
An amateur herpetologist experienced an unusual allergic reaction to Crotalidae Polyvalent antivenom after rattlesnake envenomation. This highlights potential sensitization in individuals with repeated venom/antivenom exposure.
Area of Science:
- Herpetology
- Toxicology
- Immunology
Background:
- A patient with a history of copperhead envenomation and self-administered venom/antivenom skin testing received Crotalidae Polyvalent antivenom for rattlesnake envenomation.
- The patient was an amateur herpetologist with extensive self-experimentation involving snake venom and antivenom.
Observation:
- The patient developed chills, diaphoresis, and generalized urticaria approximately 5 hours post-antivenom administration.
- This reaction occurred following treatment for a Crotalus atrox envenomation.
Findings:
- The observed reaction suggests a potential hypersensitivity to the antivenom.
- Previous exposure through skin testing may have led to unusual sensitization.
Implications:
- Unusual antivenom reactions in individuals with access to venom and antivenom warrant further investigation into sensitization mechanisms.
- This case emphasizes the need for caution and thorough patient history in managing snakebite victims, particularly those with unique exposure profiles.