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The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
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Discrimination learning in Rora(sg) and Grid2(ho) mutant mice.

R Lalonde1, C Strazielle

  • 1Centre Hospitalier de l'Université de Montréal/St-Luc, Unité de Recherche en Sciences Neurologiques, 1058 St-Denis St., Montréal, Que. H2X3J4, Canada. robert.lalonde@umontreal.ca

Neurobiology of Learning and Memory
|June 28, 2008
PubMed
Summary

Mice with cerebellar damage show impaired learning in some tasks, particularly in reversing decisions. These findings highlight the cerebellum

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Genetics

Background:

  • The cerebellum plays a crucial role in motor control and increasingly recognized for its involvement in cognitive functions, including learning.
  • Cerebellar granule cell degeneration and Purkinje cell atrophy are key pathological features in certain neurological mutations.

Purpose of the Study:

  • To investigate the impact of cerebellar granule cell degeneration on instrumental learning and reversal learning.
  • To compare the learning abilities of Rora(sg) and Grid2(ho) mutants with varying degrees of cerebellar pathology.

Main Methods:

  • Utilizing a water-filled T-maze to assess learning and memory in mouse models.
  • Comparing Rora(sg) and Grid2(ho) mutants against control groups in left-right and dark-light discrimination tasks.

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Last Updated: Jul 4, 2026

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  • Evaluating performance during acquisition, reversal training, and passive avoidance learning.

    • Main Results:

    • Both Rora(sg) and Grid2(ho) mutants exhibited slowed acquisition in the light-dark discrimination task but not in left-right discrimination.
    • Mutant mice were significantly impaired during reversal training for both tasks, indicating perseverative tendencies.
    • No significant differences were observed between mutants and controls in passive avoidance learning.

    Conclusions:

    • Cerebellar damage, specifically granule cell degeneration, affects specific types of instrumental learning in mice.
    • Mice with cerebellar damage display perseverative behaviors, struggling to adapt choices during reversal learning.
    • These findings underscore the cerebellum's role beyond motor control, extending to cognitive flexibility and adaptive learning.