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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
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Thrombophilic polymorphisms in Israel

Avshalom Zoossmann-Diskin1, Ephraim Gazit, Leah Peleg

  • 1Department of Haematology and Genetic Pathology, School of Medicine, Flinders University, Adelaide, Australia. avshalom.zoossmann-diskin@flinders.edu.au

Blood Cells, Molecules & Diseases
|June 28, 2008
PubMed

Three thrombophilic polymorphisms, FV G1691A, FII G20210A and MTHFR C677T were investigated in Israeli populations by FRET, (fluorescence resonance energy transfer) real-time PCR. We observe extensive variability in the frequencies of each of the polymorphisms, as has been observed in the study of other polymorphisms in these populations. Very high allele frequencies for FV G1691A (the highest 0.087 in Turkish and Greek Jews) and FII G20210A (the highest 0.061 in Georgian Jews) in some of the Israeli populations justify a clinical investigation to assess their risk for venous thrombosis. Principal Coordinates Analysis demonstrates that the Jewish populations are interspersed among the non-Jewish populations. The resemblance of some Jewish populations to certain non-Jewish populations coincides with findings based on classical markers.

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