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Updated: Jan 26, 2026

Detection of Enterohemorrhagic Escherichia Coli Colonization in Murine Host by Non-invasive In Vivo Bioluminescence System
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Colonization dynamics of ampicillin-resistant Escherichia coli in the infantile colonic microbiota

Nahid Karami1, Charles Hannoun, Ingegerd Adlerberth

  • 1Department of Clinical Bacteriology and Virology, University of Gothenburg, Gothenburg, Sweden. nahid.karami@microbio.gu.se

The Journal of Antimicrobial Chemotherapy
|June 28, 2008
PubMed

Insights

Ampicillin-resistant Escherichia coli strains colonize infant guts as effectively as susceptible strains. Beta-lactamase genes persist, suggesting slow elimination from the commensal E. coli pool.

Area of Science:

  • Microbiology
  • Infant Gut Microbiota
  • Antibiotic Resistance

Background:

  • The infantile gut microbiota is crucial for immune development.
  • Understanding the dynamics of antibiotic-resistant bacteria in infants is essential.

Purpose of the Study:

  • To compare colonization dynamics of ampicillin-resistant and susceptible Escherichia coli in infants.
  • To investigate factors associated with ampicillin resistance in E. coli.

Main Methods:

  • Quantitative fecal cultures in 128 infants over the first year.
  • Analysis of E. coli resistance patterns, beta-lactamase genes, phylogenetic groups, and virulence genes.

Main Results:

  • 12% of E. coli strains were ampicillin-resistant, often carrying bla(TEM) or bla(SHV) genes.
  • Ampicillin-resistant strains, mainly group D, frequently carried pap genes, associated with bla(SHV).
  • Resistance was observed in infants without prior beta-lactam exposure; resistant strains persisted equally well.

Conclusions:

  • Ampicillin-resistant E. coli demonstrate unimpaired colonization capacity in infants.
  • Beta-lactamase genes may be slowly eliminated from the commensal E. coli population.
Abstract

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