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Related Experiment Video

Updated: Jul 4, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Serum calcium as prognosticator in ischemic stroke.

Bruce Ovbiagele¹, Sidney Starkman, Philip Teal

¹Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA. Ovibes@mednet.ucla.edu

|June 28, 2008

Summary

Elevated serum calcium levels 72 to 96 hours after ischemic stroke correlate with better long-term independence. Early calcium levels showed no significant impact on stroke outcomes.

Related Experiment Videos

Last Updated: Jul 4, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Area of Science:

Neurology
Biochemistry
Clinical Medicine

Background:

Calcium ions (Ca(2+)) are implicated in neuronal death pathways following ischemic events.
Understanding the prognostic value of calcium levels in acute ischemic stroke is crucial for patient management.

Purpose of the Study:

To investigate the association between early and delayed serum calcium levels and clinical outcomes in patients with acute ischemic stroke.
To determine if calcium levels can serve as a predictive biomarker for stroke recovery.

Main Methods:

Analysis of 826 subjects from the Virtual International Stroke Trials Archive.
Categorization of serum calcium levels into quartiles at two time points: early (<4.5 hours) and delayed (72-96 hours) post-stroke onset.
Evaluation of stroke severity, functional independence (Barthel Index), and global disability using regression analyses.

Main Results:

Delayed serum calcium levels (72-96 hours) in the highest quartile were significantly associated with reduced stroke severity and improved 3-month functional outcomes compared to the lowest quartile (P<0.001).
Multivariable analysis confirmed that higher delayed calcium levels independently predicted a greater 3-month independence score on the Barthel Index (P=0.006).
No significant associations were found between early serum calcium levels and any of the analyzed clinical outcomes.

Conclusions:

Elevated serum calcium levels measured 72-96 hours after ischemic stroke are an independent predictor of greater functional independence at 3 months.
Very early serum calcium measurements (<4.5 hours) do not appear to have prognostic value for clinical outcomes in ischemic stroke.