Protein S-100 is present in extracerebral fluids before and after cardiac surgery in children

Area of Science:

• Biochemistry
• Pediatric Surgery
• Clinical Chemistry

Background:

• Protein S-100 is known to be present in extracerebral sources.
• Understanding its levels in pediatric surgical contexts is crucial for fluid analysis.

Purpose of the Study:

• To investigate the concentration of protein S-100 in native pericardial fluid.
• To analyze protein S-100 levels in postoperative extracerebral fluids (pleural, peritoneal, pericardial) following pediatric cardiac surgery.

Main Methods:

• Prospective study involving 90 pediatric patients undergoing cardiac surgery.
• Measurement of protein S-100 concentration in pericardial fluid immediately after pericardial sac opening.
• Analysis of protein S-100 in pleural, peritoneal, and pericardial fluids collected postoperatively.

Main Results:

• Preoperative pericardial fluid showed a protein S-100 content of 3.2 microg/L.
• Postoperative fluid analysis revealed protein S-100 levels of 0.89 microg/L (pleural), 0.14 microg/L (peritoneal), and 2.75 microg/L (pericardial).
• Protein S-100 concentrations in pericardial fluid did not significantly change before and after surgery, and were significantly higher than in pleural and peritoneal fluids.

Conclusions:

• Protein S-100 is demonstrably present in various extracerebral fluids in children undergoing cardiac surgery.
• The timing of fluid collection post-operation did not significantly impact protein S-100 concentrations.
• Pericardial fluid consistently shows higher protein S-100 levels compared to pleural and peritoneal fluids in this pediatric cohort.