Pharmacological approach to therapy of glomerulonephritis

Since glomerulonephritis is a typical inflammation, we are approaching the time when inhibitors of the mediators of inflammation will be used to modify the course of nephritides. In this category are thromboxane synthetase inhibitors and thromboxane antagonists as well as anti-leukotriene and anti-platelet activating factor agents. Corticosteroids are often limited by their side effects. Other approaches include the use of heparins, endothelin antagonists and E prostaglandins. This article presents the background knowledge to these considerations.