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Related Experiment Video

Updated: Jul 4, 2026

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells
09:53

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells

Published on: December 31, 2009

Continuous molecular enrichment in microfluidic systems.

Oliver K Castell1, Christopher J Allender, David A Barrow

  • 1Molecular Recognition Research Unit, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, UK. castellok@cardiff.ac.uk

Lab on a Chip
|June 28, 2008
PubMed
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This study demonstrates efficient molecular extractions using continuous flow microfluidics and segmented flow for rapid mixing. This technique enhances sample preparation and purification in chemical synthesis.

Area of Science:

  • Analytical Chemistry
  • Chemical Engineering
  • Materials Science

Background:

  • Microfluidic systems offer advantages for chemical processes.
  • Efficient molecular extraction is crucial for sample preparation and purification.
  • Rapid mixing is key to improving reaction and extraction efficiency.

Purpose of the Study:

  • To demonstrate highly efficient molecular extractions in continuous flow microfluidic systems.
  • To leverage biphasic segmented flow for enhanced mixing.
  • To utilize suspended micro-particulate adsorbents for purification.

Main Methods:

  • Utilized continuous flow microfluidic systems.
  • Employed biphasic segmented flow for rapid mixing.
  • Incorporated suspended micro-particulate adsorbents for molecular adsorption.

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Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
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Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

Published on: February 1, 2022

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Last Updated: Jul 4, 2026

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells
09:53

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells

Published on: December 31, 2009

Label-free Isolation and Enrichment of Cells Through Contactless Dielectrophoresis
10:38

Label-free Isolation and Enrichment of Cells Through Contactless Dielectrophoresis

Published on: September 3, 2013

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
08:43

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

Published on: February 1, 2022

Main Results:

  • Achieved highly efficient molecular extractions.
  • Demonstrated the effectiveness of rapid mixing via segmented flow.
  • Showcased the utility of micro-particulate adsorbents in flow systems.

Conclusions:

  • Continuous flow microfluidics with segmented flow and adsorbents enable efficient molecular extraction.
  • This technique has potential for on-line sample enrichment, purification, and clean-up.
  • The method is applicable to chemical synthesis and advanced sample preparation.