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Updated: Jul 4, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
[Management of periprosthetic infection]
1c/o ENDO-Klinik, Holstenstrasse 2, 22767, Hamburg, Deutschland. christian.friesecke@endo.de
Abstract:
Periprosthetic infection is a permanent risk and severe complication in joint arthroplasty. Systematic diagnostics under optimal conditions are necessary for a successful therapy. Patient history, clinical examination and an elevated CRP-level is the basis for suspicion of infection. The diagnosis is confirmed by identification of the pathogen from a sample collected through joint aspiration under sterile conditions. The microbiological examination is done in a laboratory specialized in the diagnosis of foreign body infections. The pattern of resistance of the identified pathogen determines the topical and systemic course of antibiotics. Surgical treatment is characterized by exchange of the prosthesis and radical debridement. The exchange can be carried out in one or two stages. The one-stage exchange offers several advantages compared to two or more stage procedures for all those involved - patient, surgeon and health care system - while providing the same chance of successful elimination of infection, with even better functional results.
Insights
Periprosthetic joint infection diagnosis relies on patient history, clinical exams, and CRP levels. One-stage prosthesis exchange surgery offers advantages for treating these infections with successful outcomes.
Area of Science:
- Orthopedics
- Infectious Diseases
- Microbiology
Context:
- Periprosthetic joint infection is a significant complication following arthroplasty.
- Accurate diagnosis and effective treatment are crucial for patient outcomes.
- Systematic diagnostic approaches are essential for successful therapeutic interventions.
Purpose:
- To outline the diagnostic pathway for periprosthetic joint infections.
- To describe the microbiological examination and antibiotic treatment strategies.
- To evaluate the efficacy and advantages of one-stage prosthesis exchange surgery.
Summary:
- Suspicion of periprosthetic infection arises from patient history, clinical examination, and elevated C-reactive protein (CRP) levels.
- Diagnosis is confirmed by pathogen identification via sterile joint aspiration and specialized microbiological analysis.
- Treatment involves prosthesis exchange and debridement, with one-stage exchange offering benefits over multi-stage procedures for infection eradication and functional results.
Impact:
- Optimized diagnostic protocols can lead to earlier and more accurate identification of periprosthetic infections.
- Tailored antibiotic regimens based on pathogen resistance patterns improve treatment efficacy.
- The one-stage prosthesis exchange approach presents a potentially superior surgical option, enhancing patient recovery and healthcare efficiency.
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