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Updated: Jul 4, 2026
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
Soft tissue sarcoma in the setting of chronic cutaneous graft versus host disease after allogenic bone marrow
Kevin C Bylund1, Ellen Giampoli, Deepinder Singh
1University of Rochester School of Medicine, Rochester, New York 14642, USA. kevin bylund@urmc.rochester.edu
Abstract:
Second primary cancers are approximately 2.1-2.8 times more common in survivors of bone marrow transplant than in the age-matched general population. We describe a patient who developed high-grade sarcoma in two disparate sites that were clinically involved by chronic cutaneous graft versus host disease (GVHD). This occurred 3.5 years after bone marrow transplant for acute myelogenous leukemia (AML). This suggests that malignant sarcomas may develop in the setting of chronic GVHD, and close surveillance of GVHD-related nodules is warranted.
