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Corneal Donor Tissue Preparation for Endothelial Keratoplasty

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Published on: June 12, 2012

Corneal endotheliitis.

Takashi Suzuki¹, Yuichi Ohashi

¹Department of Ophthalmology, Ehime University School of Medicine, Ehime, Japan.

Seminars in Ophthalmology

|June 28, 2008

Summary

Corneal endotheliitis, an inflammation of the corneal endothelium often caused by viruses, presents with edema and precipitates. Treatment with antivirals and corticosteroids is usually effective, but some cases may lead to irreversible endothelial dysfunction.

Area of Science:

Ophthalmology
Infectious Diseases
Corneal Diseases

Background:

Corneal endotheliitis is an inflammatory condition primarily affecting the corneal endothelium.
It presents with characteristic signs such as corneal edema, keratic precipitates, and mild anterior chamber reaction.
Viral infections, including herpes simplex virus, varicella zoster virus, and cytomegalovirus, are increasingly implicated in its etiology.

Purpose of the Study:

To provide a comprehensive overview of corneal endotheliitis.
To discuss the clinical classification and management of this condition.
To highlight potential long-term complications of corneal endotheliitis.

Main Methods:

Review of clinical manifestations and diagnostic criteria for corneal endotheliitis.

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Analysis of current treatment strategies, including antiviral and corticosteroid therapies.

Discussion of the pathophysiology and etiological factors, with a focus on viral involvement.

Main Results:

Corneal endotheliitis can be clinically categorized into four distinct forms: linear, sectorial, disciform, and diffuse.
Combined antiviral and topical corticosteroid therapy demonstrates general efficacy in suppressing inflammation.
A subset of patients may experience irreversible corneal endothelial dysfunction despite treatment.

Conclusions:

Corneal endotheliitis is a viral-induced inflammatory disorder of the corneal endothelium.
Prompt diagnosis and appropriate management are crucial for controlling inflammation and preserving visual function.
Awareness of potential irreversible endothelial damage is essential for patient counseling and long-term follow-up.