Related Experiment Video
Updated: Jul 4, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Human metapneumovirus: an emerging respiratory pathogen
Joseph P Mazzoncini1, Christopher B Crowell, Christopher S Kang
1Department of Emergency Medicine, Madigan Army Medical Center, Fort Lewis, Washington, USA.
Abstract:
Human metapneumovirus (hMPV) is an important emerging respiratory pathogen, previously unreported in the Emergency Medicine literature. It is primarily associated with the clinical syndromes of bronchiolitis and pneumonia. hMPV may predispose to bacterial pneumonia; coinfection with respiratory syncytial virus may lead to increased severity of clinical disease, and complications include asthma and chronic obstructive pulmonary disease exacerbations. Given its high prevalence and potential clinical implications as these patients present to the Emergency Department with initial infection or subsequent complications, a better understanding of hMPV will aid in their care. We report the case of a 13-month old who developed lobar pneumonia 3 weeks after being diagnosed with hMPV. The epidemiology, clinical presentation, complications, and treatment of hMPV are then discussed.
Insights
Human metapneumovirus (hMPV) is an emerging respiratory virus causing bronchiolitis and pneumonia. Understanding hMPV is crucial for emergency medicine, especially concerning potential complications like bacterial pneumonia and asthma exacerbations.
Area of Science:
- Pediatric Emergency Medicine
- Virology
- Infectious Diseases
Background:
- Human metapneumovirus (hMPV) is an emerging respiratory virus.
- It is a significant cause of bronchiolitis and pneumonia in children.
- hMPV has not been widely reported in emergency medicine literature.
Observation:
- A case of a 13-month-old child with hMPV infection is presented.
- The child developed lobar pneumonia three weeks post-diagnosis.
- This highlights potential delayed complications of hMPV.
Findings:
- hMPV is associated with significant respiratory illness.
- Coinfection with other viruses like RSV can increase disease severity.
- Complications include bacterial pneumonia, asthma, and COPD exacerbations.
Implications:
- Increased awareness of hMPV in emergency departments is needed.
- Early diagnosis and management can improve patient outcomes.
- Further research into hMPV epidemiology and complications is warranted.
More Related Videos
11:32Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
09:01An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Related Concept Videos
Respiratory Syncytial Virus Disease
Atypical Pneumonia
Pneumonia I: Introduction
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia II: Pathophysiology
Microbiota of the Respiratory Tract