Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Unrenewable Cells00:50

Unrenewable Cells

In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ototoxicity-related changes in GABA immunolabeling within the rat inferior colliculus.

Hearing research·2024
Same author

Human-Induced Pluripotent Stem Cell (iPSC)-Derived GABAergic Neuron Differentiation in Bipolar Disorder.

Cells·2024
Same author

Wavelet transform of single-trial vestibular short-latency evoked potential reveals temporary reduction in signal detectability and temporal precision following noise exposure.

bioRxiv : the preprint server for biology·2024
Same author

Cohort Profile Update: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder.

International journal of epidemiology·2023
Same author

Noise overstimulation of young adult UMHET4 mice accelerates age-related hearing loss.

Hearing research·2022
Same author

DNAzyme-Based Lithium-Selective Imaging Reveals Higher Lithium Accumulation in Bipolar Disorder Patient-Derived Neurons.

ACS central science·2021
Same journal

TGF-β signaling regulates flat epithelium formation in severely injured adult mouse utricle through epithelial-mesenchymal transition.

Hearing research·2026
Same journal

Membrane scaffolding in auditory hair cells - a molecular tightrope walk enables lateral wall stiffness and flexibility.

Hearing research·2026
Same journal

Speech-in-noise recognition during hearing protector use: Human performance and acoustic prediction.

Hearing research·2026
Same journal

Estimation of hair cell loss from audiograms.

Hearing research·2026
Same journal

Cochlear size variation in a large-scale international multicentre cohort.

Hearing research·2026
Same journal

Estimation of minor-to-moderate conductive hearing loss with distortion-product otoacoustic emissions in humans.

Hearing research·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2026

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
09:34

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

Stem cell transplantation for auditory nerve replacement.

Richard A Altschuler1, K Sue O'Shea, Josef M Miller

  • 1Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150W. Medical Center Drive, Ann Arbor, MI 48109-5616, United States. shuler@umich.edu

Hearing Research
|July 1, 2008
PubMed
Summary
This summary is machine-generated.

Stem cells show promise for replacing auditory nerve neurons, potentially improving cochlear implant function and expanding eligibility. Research explores both external stem cell transplantation and internal progenitor cell activation for auditory nerve repair.

More Related Videos

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
10:33

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Published on: February 23, 2014

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

Related Experiment Videos

Last Updated: Jul 4, 2026

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
09:34

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
10:33

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Published on: February 23, 2014

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Otolaryngology

Background:

  • Cochlear prosthesis efficacy relies on auditory nerve activation.
  • Auditory nerve neuron survival varies, impacting cochlear implant outcomes.
  • Stem cells offer a potential solution for auditory nerve regeneration.

Purpose of the Study:

  • To review existing research on stem cell replacement of the auditory nerve.
  • To present new findings on in vivo stem cell differentiation in the cochlea.
  • To explore endogenous progenitors as an alternative for auditory nerve repair.

Main Methods:

  • In vitro and in vivo studies of exogenous embryonic and tissue stem cells.
  • Placement of B-5 mouse embryonic stem cells into guinea pig cochleae.
  • Investigation of stem cell-derived neuron integration and endogenous progenitor identification.

Main Results:

  • Exogenous stem cells demonstrated survival and differentiation in vivo.
  • B-5 mouse embryonic stem cells differentiated into glutamatergic neurons in the guinea pig cochlea.
  • Evidence suggests endogenous progenitors in cochlear/vestibular tissues could be utilized.

Conclusions:

  • Stem cell therapy holds potential for auditory nerve regeneration.
  • Both exogenous and endogenous stem cell approaches warrant further investigation.
  • Successful auditory nerve replacement could enhance cochlear implant function.