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Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy

Vanessa Roldán1, Francisco Marín, Juan R Gimeno

  • 1Centro Regional de Hemodonación, University of Murcia, Murcia, Spain.

American Heart Journal
|July 1, 2008
PubMed

Insights

Matrix metalloproteinase 9 is linked to cardiac fibrosis in hypertrophic cardiomyopathy (HCM). This finding highlights the role of the matrix metalloproteinase system in HCM remodeling and fibrosis.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) involves unexplained left ventricular hypertrophy, myocyte disarray, and interstitial fibrosis due to increased collagen.
  • Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) indicates myocardial fibrosis.
  • Matrix metalloproteinases (MMPs) are implicated in myocardial remodeling and fibrosis.

Purpose of the Study:

  • To investigate the relationship between the MMP system, CMR-documented fibrosis (LGE), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in HCM patients.

Main Methods:

  • 67 HCM patients and 58 controls underwent CMR with gadolinium.
  • Plasma levels of MMP-1, MMP-2, and MMP-9 were measured using ELISA.
  • Serum NT-proBNP levels were quantified.

Main Results:

  • HCM patients showed elevated MMP-2, MMP-9, and NT-proBNP levels.
  • MMP-9 was significantly associated with gadolinium enhancement on CMR (P = .001) and correlated with NT-proBNP (r = 0.52, P < .001).
  • MMP-9 was independently associated with fibrosis on multivariate analysis (P = .011).

Conclusions:

  • Matrix metalloproteinase 9 is independently associated with myocardial fibrosis in HCM, as evidenced by gadolinium enhancement on CMR.
  • The MMP system plays a significant role in cardiac remodeling and fibrosis within the context of HCM.
Abstract

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