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Levofloxacin-induced delirium with psychotic features
Boonsong Kiangkitiwan1, Avanthi Doppalapudi, Margaret Fonder
1Department of Internal Medicine, Greater Baltimore Medical Center, Baltimore, MD 21204, USA.
General Hospital Psychiatry
|July 1, 2008
Summary
Levofloxacin, a common antibiotic, can rarely cause acute delirium with psychotic features, even in young, healthy individuals. Promptly stopping the medication can reverse these central nervous system adverse effects.
Area of Science:
- Pharmacology
- Neuroscience
- Infectious Diseases
Background:
- Quinolone antibiotics, including levofloxacin, are widely prescribed.
- Central nervous system (CNS) adverse effects are known but rare complications.
- Delirium with psychotic features is an exceptionally uncommon presentation.
Observation:
- A 42-year-old woman developed acute delirium with psychotic features.
- The patient was previously healthy and undergoing levofloxacin therapy.
- Symptoms resolved upon discontinuation of levofloxacin.
Findings:
- This case highlights levofloxacin-induced delirium with psychotic features in a young, healthy female.
- This presentation is rare and typically associated with elderly patients or those with pre-existing CNS conditions or renal insufficiency.
- Levofloxacin, a gyrase inhibitor, can affect the central nervous system.
Implications:
- Clinicians should consider levofloxacin-induced neurotoxicity in patients presenting with acute delirium, regardless of age.
- Awareness of this rare adverse effect is crucial for timely diagnosis and management.
- Further research may elucidate specific risk factors for this severe CNS complication.
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