Related Experiment Video
Updated: Jul 4, 2026
Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
Published on: March 28, 2025
Echinococcus granulosus: induction of T-independent antibody response against protoscolex glycoconjugates in early
Adriana Baz1, Hernán Carol1, Verónica Fernández1
1Cátedra de Inmunología, Dpto. Biociencias, Facultad de Química, Universidad de la República, Casilla de Correos 1157, Montevideo, Uruguay.
Abstract:
In this work CD4-knockout mice were used as a model to analyse the role of CD4+ T cells in the antibody response against Echinococcus granulosus immunization or experimental infection. Results obtained with mice immunized with protoscolex antigens indicated that these contain T-independent antigens. After infection, CD4-knockout mice and C57Bl/6 mice showed similar titres of specific antibodies indicating that T-independent antibody production was quantitatively important in early infection. We have also identified an antigenic fraction from protoscoleces (E4+) which induces CD4 T cell independent antibody response in early stages of infection. In conclusion, the results presented here directly support the existence of T-independent immunogens in E. granulosus protoscoleces and suggest that T-independent antibody response may be quantitatively important in early infection.
