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Related Experiment Video

Updated: Jul 4, 2026

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources
12:39

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources

Published on: November 26, 2016

A mouse model for studying large-scale neuronal networks using EEG mapping techniques.

Pierre Mégevand1, Charles Quairiaux, Agustina M Lascano

  • 1Fundamental Neuroscience Department, Geneva University Medical School, Rue Michel-Servet 1, 1211 Geneva 14, Switzerland.

Neuroimage
|July 1, 2008
PubMed
Summary

We developed a minimally invasive epicranial electroencephalography (EEG) method to study large-scale neuronal networks in mice. This technique allows detailed investigation of brain network dynamics and plasticity.

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Last Updated: Jul 4, 2026

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Neurophysiology

Background:

  • Human functional imaging studies identify large-scale neuronal networks, but a similar method for rodents is needed for detailed molecular and neuronal investigation.
  • Understanding rodent brain networks is crucial for studying development, plasticity, and recovery after lesions.

Purpose of the Study:

  • To present a minimally invasive method for studying large-scale neuronal networks in mice using epicranial electroencephalography (EEG).
  • To quantify the dynamics of global neuronal activation with sub-millisecond resolution.
  • To validate the method's feasibility, stability, and reproducibility.

Main Methods:

  • Simultaneous recording of epicranial EEG from 32 electrodes distributed over the mouse head surface.
  • Spatiotemporal analysis of electrical potential maps to quantify global neuronal activation dynamics.
  • Comparison with 16-channel intracortical local field potential recordings across cortical layers.

Main Results:

  • The method successfully recorded electrical activity evoked by mystacial vibrissae stimulation, revealing large-scale network activation.
  • Identified network generators in somatosensory and motor areas across both hemispheres.
  • Demonstrated stable spatiotemporal activation patterns across mice and over time, with concordance to intracortical recordings.

Conclusions:

  • Epicranial EEG mapping is a feasible, stable, and reproducible method for assessing sensory processing by large-scale neuronal networks in mice.
  • This minimally invasive technique complements existing approaches for detailed study of network neurophysiology, development, plasticity, and lesion recovery.
  • Enables in-depth investigation of neuronal and molecular mechanisms within these networks in various animal models.