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Related Experiment Video

Updated: Jul 4, 2026

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking
05:49

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

CT data-based navigation for post-mortem biopsy--a feasibility study.

Emin Aghayev1, Lars C Ebert, Andreas Christe

  • 1Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, CH-3012 Bern, Switzerland. emin.aghayev@memcenter.unibe.ch

Journal of Forensic and Legal Medicine
|July 1, 2008
PubMed
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This study demonstrates that navigated post-mortem biopsy accurately obtains tissue samples from various body locations with minimal needle insertions. This method enhances safety by reducing radiation exposure for investigators during minimally invasive procedures.

Area of Science:

  • Medical Imaging
  • Forensic Pathology
  • Minimally Invasive Procedures

Background:

  • Advances in medical imaging have increased interest in post-mortem minimally invasive computed tomography (CT) guided percutaneous biopsy.
  • Current methods may involve radiation exposure and multiple needle attempts for tissue sampling.

Purpose of the Study:

  • To facilitate and automate post-mortem biopsy procedures.
  • To minimize radiation exposure to investigators during CT-guided tissue sampling.
  • To reduce the number of needle insertion attempts per target to a single puncture.

Main Methods:

  • Utilized clinically approved 14-gauge biopsy core needles with an automatic pistol device.
  • Employed a navigation system with a guidance frame and CT for probe sampling.

Related Experiment Videos

Last Updated: Jul 4, 2026

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking
05:49

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

  • Tested the system in a phantom model, ex vivo porcine model, and two human bodies.

    • Main Results:

    • Achieved accurate biopsy of targets in phantoms and porcine liver with minimal needle tip deviation (1.4mm and 0.5mm average distances, respectively).
    • Successfully performed biopsies from multiple organs (brain, heart, lung, liver, pancreas, spleen, kidney) in human corpses.
    • Completed tissue sampling from one body in approximately 45 minutes, with each target requiring only one needle insertion.

    Conclusions:

    • Navigated post-mortem biopsy reliably yields tissue samples from diverse anatomical sites.
    • Optical tracking eliminates the need for verification CT scans, thereby preventing radiation exposure.
    • The technique ensures high accuracy with single needle insertions, allowing for oblique angles, and is a valuable addition to post-mortem CT-guided biopsy.