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Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

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Related Experiment Video

Updated: Jul 4, 2026

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

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Published on: February 8, 2018

Bilateral decrease in ventrolateral prefrontal cortex activation during motor response inhibition in mania.

Pascale Mazzola-Pomietto1, Arthur Kaladjian, Jean-Michel Azorin

  • 1Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193, CNRS-Université de la Méditerranée, 13402 Marseille Cedex 20, France. pascale.mazzola-pomietto@univmed.fr

Journal of Psychiatric Research
|July 1, 2008
PubMed
Summary
This summary is machine-generated.

Individuals with mania exhibit impaired motor response inhibition, evidenced by reduced activation in the ventrolateral prefrontal cortex (VLPFC). This brain region is crucial for suppressing irrelevant responses, potentially explaining manic impulsivity.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Mania is characterized by impaired inhibitory control.
  • Understanding the neural basis of this deficit is crucial for developing targeted treatments.

Purpose of the Study:

  • To identify specific brain functional abnormalities related to motor response inhibition in mania.
  • To investigate the role of the ventrolateral prefrontal cortex (VLPFC) in manic impulsivity.

Main Methods:

  • Event-related functional magnetic resonance imaging (fMRI) was employed.
  • A Go/NoGo task was administered to 16 manic patients and 16 healthy controls.
  • Analyses of covariance controlled for extraneous cognitive processes.

Main Results:

  • No significant differences in task performance accuracy were observed between groups.
  • Manic patients exhibited longer response times on Go trials.
  • Significantly decreased activation in the bilateral ventrolateral prefrontal cortex (VLPFC) was found in manic patients during motor response inhibition.

Conclusions:

  • Motor response inhibition in mania is associated with reduced engagement of the bilateral VLPFC.
  • This VLPFC dysfunction may underlie the disinhibition and impulsivity seen in mania.
  • Findings offer insights into the pathophysiology of mania.