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Validated methods for degrading hazardous chemicals: some halogenated compounds.

G Lunn1, E B Sansone

  • 1Program Resources, Inc., NCI-Frederick Cancer Research and Development Center, MD 21702-1201.

American Industrial Hygiene Association Journal
|June 1, 1991
PubMed
Summary

This study explored two chemical methods for degrading halogenated compounds. Both techniques successfully broke down various substances, yielding nonmutagenic products.

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Area of Science:

  • Organic Chemistry
  • Environmental Chemistry
  • Green Chemistry

Background:

  • Halogenated organic compounds are widely used but pose environmental and health risks.
  • Effective degradation methods are crucial for managing hazardous halogenated waste.
  • Previous methods often involve harsh conditions or incomplete degradation.

Purpose of the Study:

  • To investigate two distinct chemical techniques for the degradation of diverse halogenated organic compounds.
  • To assess the efficacy of reductive dehalogenation and alkaline hydrolysis in breaking down these substances.
  • To determine the nature of the degradation products and their potential mutagenicity.

Main Methods:

  • Reductive dehalogenation using nickel-aluminum alloy in potassium hydroxide solution.

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  • Alkaline hydrolysis by refluxing with ethanolic potassium hydroxide.
  • Analysis of degradation products to identify resulting compounds and assess mutagenicity.

    • Main Results:

    • Reductive dehalogenation successfully degraded a wide range of halogenated compounds, primarily replacing halogens with hydrogen.
    • Alkaline hydrolysis yielded corresponding ethyl ethers from various halogenated substrates.
    • Cleavage of 2-methylaziridine produced a mixture of amines.
    • All reaction mixtures were found to be nonmutagenic.

    Conclusions:

    • Both investigated methods offer effective pathways for the complete degradation of various halogenated compounds.
    • The choice of method influences the specific products formed, with potential for targeted synthesis.
    • The nonmutagenic nature of the products suggests these methods are environmentally favorable for waste treatment.