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Fluoxetine's effect on weight loss in obese subjects
L L Darga1, L Carroll-Michals, S J Botsford
1Division of Preventive and Nutritional Medicine, William Beaumont Hospital, Royal Oak, MI 48009.
The American Journal of Clinical Nutrition
|August 1, 1991
Summary
Fluoxetine aided significant weight loss in obese individuals, but weight regain occurred later. While both groups lost weight, fluoxetine
Area of Science:
- Pharmacology
- Obesity Research
- Clinical Trials
Background:
- Obesity is a major health concern with limited effective long-term treatments.
- Pharmacological interventions are explored to aid weight management in obese populations.
Purpose of the Study:
- To evaluate the efficacy of fluoxetine combined with diet for weight loss in obese subjects.
- To compare weight loss outcomes between fluoxetine-diet and placebo-diet groups over 52 weeks.
Main Methods:
- Randomized controlled trial involving 45 obese subjects (BMI 37.6 kg/m2).
- Subjects were assigned to either a fluoxetine-diet group (n=23) or a placebo-diet group (n=22).
- Weight changes were monitored over a 52-week period.
Main Results:
- The fluoxetine group achieved significantly greater maximum weight loss (12.4 kg) compared to placebo (4.5 kg) by week 29.
- This significant weight loss advantage for fluoxetine persisted through week 45.
- However, the fluoxetine group experienced significant weight regain (4.2 kg) from their lowest weight, unlike the placebo group.
Conclusions:
- Fluoxetine, when combined with diet, initially promotes greater weight loss in obese individuals.
- Long-term effectiveness is challenged by significant weight regain in the fluoxetine group.
- Further investigation is needed to understand and mitigate weight regain associated with fluoxetine treatment.