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Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid
B J Burri1, R M Dougherty, D S Kelley
1US Department of Agriculture/Agriculture Research Service, Western Human Nutrition Research Center, Presidio of San Francisco, CA 94129.
Abstract:
The effect of concentrations of linoleic acid (LA) on platelet aggregation was measured in seven healthy adult males. Subjects were randomly divided into two groups; these groups were fed natural food diets of identical composition except that one was high in LA (11.5% of energy) and low in oleic acid (OA) (7.4% of energy), the other was low in LA (4.5% of energy) and high in OA (15.7% of energy). The thresholds of ADP- and collagen-induced platelet aggregation were increased significantly by the high LA diet even though the intake of total fat and saturated fatty acids did not differ in these diets.