Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Radiologists are increasingly recommending follow-up of chest radiographs: a 10-year review.

Irish journal of medical science·2020

Same author

Cancer research program of Oak Ridge Institute of Nuclear Studies.

The Southern surgeon·2014

Same author

RADIOSENSITIVITY IN MAN: A STUDY BASED ON THERAPEUTIC AND ACCIDENTAL EXPOSURE.RES REP. ORINS-49.

ORINS [reports]. U.S. Atomic Energy Commission·2014

Same author

OAK RIDGE INSTITUTE OF NUCLEAR STUDIES MEDICAL DIVISION--RESEARCH REPORT. ORINS-49.

ORINS [reports]. U.S. Atomic Energy Commission·2014

Same author

STUDIES RELATED TO TREATMENT OF RADIATION INJURY. RES REP. ORINS-49.

ORINS [reports]. U.S. Atomic Energy Commission·2014

Same author

METALS METABOLISM AND MEDICAL RADIOISOTOPE DEVELOPMENT. RES REP. ORINS-49.

ORINS [reports]. U.S. Atomic Energy Commission·2014

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Intracardiac ectopic thyroid carcinosarcoma in a dog.

K M Almes¹, A M Heaney, G A Andrews

¹Department of Diagnostic Medicine/ Pathobiology, Kansas State University, Manhattan, KS 66506, USA.

Veterinary Pathology

|July 1, 2008

Summary

This study reports the first case of an intracardiac ectopic thyroid carcinosarcoma in a dog. This rare heart tumor, diagnosed via histopathology, highlights a unique presentation of canine neoplasia.

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

Related Experiment Videos

Last Updated: Jul 4, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

Area of Science:

Veterinary Pathology
Canine Oncology
Cardiovascular Pathology

Background:

Ectopic thyroid tissue, normally found in the neck, can rarely develop into tumors.
Carcinosarcomas are malignant tumors with both carcinomatous and sarcomatous components.

Observation:

A 13-year-old Labrador Retriever presented with progressive exercise intolerance due to an interventricular heart mass.
Echocardiography revealed a mass protruding into the right ventricle.
Necropsy and histopathology confirmed a carcinosarcoma with features of thyroid tissue, vascular channels, and osteoid.

Findings:

Immunohistochemistry confirmed neoplastic thyroid follicular cells (thyroglobulin-positive) and neoplastic endothelium (factor VIII-related antigen-positive).
The normal thyroid gland ruled out metastasis, confirming the intracardiac mass as primary ectopic thyroid carcinosarcoma.
This represents the first documented case of an intracardiac ectopic thyroid carcinosarcoma in any species.

Implications:

This case expands the known locations for ectopic thyroid carcinosarcomas.
It underscores the importance of thorough histopathological evaluation for diagnosing rare and complex canine neoplasms.
Further research may elucidate the origins and behavior of ectopic thyroid tumors in domestic animals.