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Published on: September 20, 2020
Neoadjuvant therapy with sorafenib in advanced renal cell carcinoma with vena cava extension submitted to radical
Franco Di Silverio1, Alessandro Sciarra, Ulderico Parente
1Department of Urology, University of Rome, Rome, Italy.
Abstract:
A 71-year-old man with advanced left renal cell carcinoma (lymph node involvement and vena cava thrombus) was submitted to 6 months of neoadjuvant treatment with sorafenib before open radical nephrectomy. After sorafenib treatment and before surgery a new CT scan confirmed the presence of a 9.0 cm in diameter solid mass in the left kidney but a reduction in thrombus extension, limited to the left renal vein. At histological examination after radical nephrectomy, over 90% of the renal mass was substituted by necrotic tissue.
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