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Updated: Jul 4, 2026

Establishment of an Extracellular Acidic pH Culture System
Published on: November 19, 2017
pH and salivary sodium bicarbonate in cancer patients: correlation with seric concentration
Thais Rojas-Morales1, Rita Navas, Ninoska Viera
1Research Institute, Faculty of Dentistry, Universidad del Zulia, Maracaibo, Zulia, Venezuela. moralesrojas@cantv.net
Objective:
To determine the correlation between pH and bicarbonate of soda in blood and saliva in child and adolescent patients during the administration of 3 g/m2 of methotrexate.
Method:
A controlled clinical test was performed on 23 patients diagnosed with Acute Lymphoblastic Leukemia. Ages ranged from 4 to 18. The Spearman Correlation Coefficient was used to interpret the data.
Results:
No significant correlation was found between pH levels and seric and salivary sodium bicarbonate. However, there was a significant correlation between the levels of sodium bicarbonate in the body fluids evaluated (rs 0.2576, p=0.0354).
Conclusions:
Changes modifying the microenvironment of the oral cavity probably do not allow saliva to be used to determine blood pH and seric bicarbonate.
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