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Related Concept Videos

Knee Joint01:23

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Ankle Joint01:10

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Bones of the Upper Limb: Humerus01:19

Bones of the Upper Limb: Humerus

The upper limb consists of the arm, forearm, wrist, and hand bones. The humerus is the single bone of the upper arm region. Proximally, it has a large, spherical, smooth head that articulates with the glenoid cavity of the scapula to form the glenohumeral or shoulder joint. The margin of the head is the anatomical neck, a residual epiphyseal plate. Laterally it extends to form bony projections called the greater tubercle and the lesser tubercle. Next to the tubercles is the surgical neck, a...

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Related Experiment Video

Updated: Jul 4, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

[Arthrosis update].

S Rehart1, H Lehnert

  • 1Klinik für Orthopädie und Unfallchirurgie, Markus-Krankenhaus, Akademisches Lehrkrankenhaus der Johann Wolfgang Goethe-Universität, Wilhelm-Epstein-Strasse 2, 60431 Frankfurt a. M., Deutschland. rehart@fdk.info

Zeitschrift Fur Rheumatologie
|July 1, 2008
PubMed
Summary
This summary is machine-generated.

Arthrosis deformans, a widespread joint disease, causes pain and immobility. While current treatments manage symptoms, research into medicamentous and genetic therapies offers future healing possibilities.

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Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
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Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Published on: September 29, 2018

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Last Updated: Jul 4, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
14:49

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Published on: September 29, 2018

Area of Science:

  • Rheumatology and Orthopedics
  • Genetics and Molecular Biology

Context:

  • Arthrosis deformans is a globally prevalent degenerative joint disease affecting all ethnic groups.
  • Genetic predisposition plays a significant role in the onset and progression of arthrosis deformans.
  • The disease manifests with characteristic symptoms of pain and progressive joint stiffness.

Purpose:

  • To provide an overview of the current understanding of arthrosis deformans.
  • To highlight the challenges in treating this widespread condition.
  • To discuss the potential of emerging therapeutic strategies.

Summary:

  • Arthrosis deformans affects joints worldwide, influenced by genetic factors, leading to pain and reduced mobility.
  • Early management involves conservative treatments, while advanced stages may require surgical interventions like endoprosthesis implantation or bracing.
  • Currently, complete healing is not achievable, but research into medication and gene therapy shows promise.

Impact:

  • Informs clinicians and researchers about the multifaceted nature of arthrosis deformans.
  • Highlights the unmet need for curative treatments, driving further research and development.
  • Emphasizes the potential of novel therapeutic avenues, including genetic and pharmacological interventions, to improve patient outcomes.