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Related Concept Videos

Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
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Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
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DNA binding by Ru(II)-bis(bipyridine)-pteridinyl complexes.

Shannon R Dalton1, Samantha Glazier, Belinda Leung

  • 1Department of Chemistry, Bryn Mawr College, Bryn Mawr, PA 19010, USA.

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
|July 1, 2008
PubMed
Summary
This summary is machine-generated.

Five ruthenium(II) complexes with pteridinyl-phenanthroline ligands were studied for their interactions with DNA. These complexes bind to DNA via intercalation, with some showing stable surface binding and acting as molecular light switches.

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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

Area of Science:

  • Coordination Chemistry
  • Bioinorganic Chemistry
  • Molecular Interactions

Background:

  • Ruthenium(II) complexes are investigated for their DNA-binding properties.
  • Pteridinyl-phenanthroline ligands are designed for specific hydrogen-bonding interactions with DNA bases.

Purpose of the Study:

  • To synthesize and characterize new ruthenium(II) pteridinyl complexes.
  • To investigate the DNA binding modes and affinities of these complexes.
  • To evaluate their potential as DNA molecular "light switches".

Main Methods:

  • Synthesis of three new ruthenium(II) pteridinyl complexes.
  • DNA binding studies using absorption and fluorescence spectroscopy.
  • Viscometry and thermal denaturation titrations to determine binding modes and stability.

Main Results:

  • All synthesized Ru-pteridine complexes intercalate into calf thymus DNA with comparable strength.
  • Two complexes, [Ru(bpy)(2)(L-pterin)](2+) and [Ru(bpy)(2)(L-allox)](2+), displayed biphasic DNA melting curves, indicating stable surface binding.
  • Three complexes function as DNA molecular "light switches".

Conclusions:

  • Ruthenium(II) pteridinyl complexes exhibit diverse DNA binding behaviors, including intercalation and stable surface interactions.
  • The pteridine moiety influences DNA binding affinity and mode.
  • These complexes show promise as luminescent probes and molecular switches for DNA.