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The design of controllers for batch bioreactors.

R J Cardello¹, K Y San

¹Department of Chemical Engineering, Rice University, PO Box 1892, Houston, Texas 77251, USA.

Biotechnology and Bioengineering

|August 5, 1988

Summary

This study presents two novel control strategies for batch bioreactors to manage changing fermentation dynamics. Gain scheduling, using oxygen uptake rate, offers superior control over fixed-gain PID controllers.

Area of Science:

Biotechnology
Chemical Engineering
Control Systems

Background:

Batch bioreactor control is challenging due to dynamic process variations.
Fixed-gain PID controllers show limitations in performance across wide operating ranges.

Purpose of the Study:

To develop and evaluate advanced control algorithms for batch fermentation.
To compensate for changing process dynamics and improve control performance.

Main Methods:

Implementation of static feedforward-feedback control.
Development of a gain-scheduling controller utilizing oxygen uptake rate as an auxiliary variable.
Simulation experiments to assess controller performance.

Main Results:

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Both feedforward-feedback and gain-scheduling controllers improved performance compared to standard feedback.

The gain-scheduling controller demonstrated superior control by adapting PID parameters.

Significant performance improvements were observed even with measurement noise.

Conclusions:

Gain scheduling is an effective adaptive control strategy for batch bioreactors.
Proposed controllers offer enhanced performance for oxygen tension control in fermentation.
These methods provide robust solutions for complex bioreactor dynamics.