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Updated: Jul 4, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Kinetic model of hydrocortisone 1-en-dehydrogenation by Arthrobacter globiformis
V P Gachok1, V I Grytsay, A Y Arinbasarova
1Institute for Theoretical Physics, Ukrianian SSR, Academy of Sciences, Kiev, USSR.
Abstract:
A kinetic model of the hydrocortisone-to-prednisolone transformation by Arthrobacter globiformis is constructed using the experimental data obtained in studies of this process. Besides adequately describing experimental data, the model allows one to determine the relation between hydrocortisone oxidation and the level of endogenous substrates in bacterial cells, and the relation between the saturating concentration of hydrocortisone in the enzymic system of bacteria and the content of endogenous substrates in their cells, as well as the regulation of the transmembrane potential and the activation by the uncouplers.
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