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Protein partitioning in two-phase aqueous polymer systems.

J N Baskir¹, T A Hatton, U W Suter

¹Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Biotechnology and Bioengineering

|August 5, 1989

Summary

Protein partitioning in polymer systems is complex. Current theories explain some factors, but a universal predictive model for protein behavior is still needed.

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Area of Science:

Biochemistry
Polymer Science
Separation Science

Background:

Protein partitioning in two-phase polymer systems is crucial for bioseparations.
Existing theories address specific factors influencing protein distribution.

Purpose of the Study:

To review existing theories of protein partitioning in polymer systems.
To identify gaps in current understanding and predictive capabilities.

Main Methods:

Literature review of theoretical models for protein partitioning.
Analysis of factors including material choice, protein characteristics, and system conditions.

Main Results:

Current models offer insights into specific aspects of protein partitioning.
No comprehensive theory exists to predict protein partitioning behavior across diverse systems.

Conclusions:

Further research is needed to develop a fundamental theory for protein partitioning.
Recommendations for future work are provided to advance predictive models.