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Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats
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Neurogenesis, learning and associative strength.

Jaylyn Waddell1, Tracey J Shors

  • 1Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.

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Learning enhances the survival of new neurons in the hippocampus, particularly when the learning process requires more trials. This suggests a crucial link between neurogenesis and memory formation.

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Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • The hippocampus is vital for learning and memory.
  • The function of newly generated neurons in the hippocampus remains unclear.
  • Associative learning tasks can promote the survival of new cells in the dentate gyrus.

Purpose of the Study:

  • To investigate how manipulating learning acquisition affects the survival of new neurons in the dentate gyrus.
  • To determine if learning-induced cell survival is dependent on the expression of a conditioned response.

Main Methods:

  • Rats were trained using trace eyeblink conditioning, a procedure involving a temporal gap between conditioned and unconditioned stimuli.
  • Learning acquisition was altered by introducing unpredictable unconditioned stimuli or using latent inhibition.
  • The survival of new cells generated one week prior to training was examined.

Main Results:

  • Trace conditioning training increased the number of surviving new cells, regardless of acquisition rate or associative strength.
  • Disrupting acquisition with unsignaled unconditioned stimuli also increased cell numbers.
  • Learning that required more trials led to greater retention of new cells.

Conclusions:

  • Learning significantly enhances the survival of newly generated neurons in the dentate gyrus.
  • The positive effect of learning on cell survival is not contingent on the successful expression of a conditioned response.
  • The effectiveness of learning in promoting cell survival is correlated with the number of trials required for acquisition.