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Granulocyte-colony stimulating factor producing rectal cancer.

Hiroki Takahashi¹, Akira Yasuda, Nubuo Ochi

¹Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Japan. takahasi@med.nagoya-cu.ac.jp

World Journal of Surgical Oncology

|July 1, 2008

Summary

This report details the first documented case of granulocyte-colony stimulating factor (G-CSF)-producing rectal cancer. This rare G-CSF-producing cancer has a very poor prognosis, highlighting the need for further research.

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Area of Science:

Oncology
Gastroenterology

Background:

Granulocyte-colony stimulating factor (G-CSF)-producing cancers are typically found in the lung.
G-CSF-producing colorectal cancer (CRC) has not been previously reported in English literature.

Observation:

A 57-year-old male presented with rectal cancer and concurrent liver tumors.
Post-surgery, the patient developed a significantly elevated white blood cell count (81,000 cells/microL).
Elevated serum G-CSF levels (840 pg/mL) and positive immunohistochemistry confirmed G-CSF production by the tumor.

Findings:

The case was diagnosed as an undifferentiated G-CSF-producing rectal carcinoma with liver metastases and peritoneal dissemination.
Standard chemotherapy (Modified-FOLFOX6) was ineffective against the metastatic disease.
The patient experienced rapid disease progression and succumbed to complications within 2 months.

Implications:

This case represents the first documented instance of G-CSF-producing rectal cancer.
The extremely poor prognosis observed underscores the aggressive nature of this rare malignancy.
Further investigation into G-CSF-producing rectal cancer is warranted to understand its pathogenesis and explore potential therapeutic strategies.